Mackinnon led Portland with 23 factors within the first half to assist put them forward 42-37 on the break.
Portland hosts an unranked Gonzaga workforce on Saturday.
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SAN DIEGO (4-17) — Trouet 3-9 0-0 6, Jamerson 3-6 1-2 7, Webb 2-3 2-3 6, Duckett 5-16 4-4 14, Muncey 0-1 0-0 0, Clouet 6-13 3-3 19, Chammaa 2-6 2-2 6, Gaffney 1-4 0-1 2, Pierre 1-3 2-2 5, Dahlke 2-4 4-4 10, Brooks 1-2 1-2 4, Beniwal 1-1 0-0 3. Totals 27-68 19-23 82.
PORTLAND (7-14) — Dengdit 2-3 2-2 6, Rapp 6-17 2-2 17, Austin 5-9 8-9 20, Delano 1-2 0-0 3, Mackinnon 9-17 18-22 43, Ballew 0-3 0-0 0, Jones 1-2 1-2 3, Gebbers 0-0 0-0 0, Lemke 0-0 0-0 0. Totals 24-53 31-37 92.
Halftime—Portland 42-37. 3-Level Targets—San Diego 9-18 (Clouet 4-8, Dahlke 2-3, Beniwal 1-1, Brooks 1-1, Pierre 1-2, Duckett 0-1, Gaffney 0-1, Muncey 0-1), Portland 13-28 (Mackinnon 7-9, Rapp 3-11, Austin 2-3, Delano 1-2, Ballew 0-3). Rebounds—San Diego 36 (Jamerson 10), Portland 34 (Rapp 8). Assists—San Diego 11 (Chammaa 5), Portland 21 (Austin 5). Whole Fouls—San Diego 22, Portland 18. A—1,014 (4,852).